Chrysomycin: a new antibiotic substance for bacterial viruses.
نویسندگان
چکیده
In the course of a study of antiphage substances a yellow, crystalline antibiotic substance, which has been named Chrysomycin, was isolated from an unidentified Streptomyces. A number of yellow antibiotic substances derived from Streptomyces have recently been described, among others aureolic acid (Philip and Schenck, 1953), chartreusin (Leach et al., 1953), limocrocin (Brockmann and Grothe, 1953), phalamycin (Brown and Hazen, 1953), thioaurin (Bolhofer et al., 1953), and xanthothrycin (Machlowitz et al., 1954). Chrysomycin, which contains only carbon, hydrogen, and oxygen, does not appear to be identical with any of them although its ultraviolet spectrum shows certain similarities with that of aureolic acid.
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The biosynthetic origin of the carbon atoms in the chromophores of chrysomycins A and B was investigated in feeding experiments using 13C labeled acetates and propionate. A biosynthetic scheme is proposed involving the condensation and rearrangement of a decaketide intermediate which contains either propionate (chrysomycin A) or acetate (chrysomycin B) as the chain initiator.
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 69 3 شماره
صفحات -
تاریخ انتشار 1955